The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Zoloft side effects acid reflux. On 25mg i didn't feel any side effects, just felt a little dizzy, but on 50mg and no clonazepam, the side effects were terrible increased and debilitating anxiety, almost to the point i couldn't function sweaty hands also i started to feel depressed sad and frustrated (i didn't have depression before) hand shaking (not too much but noticeable).