Acid reflux drugs side effects ppi's (nexium, omeprazole, esomeprazole, lanzoprazole) and h2 receptor blockers (ranitidine, famotidine, cimetidine, nizatidine, zantac) both work in a different way, but have the same result: they suppress the production of stomach acid. Acid reflux medication side effects. To everybody’s information, acid reflux side effects are serious and may develop to a more severe illness click here to discover how you can get rid of your acid reflux naturally over-the-counter or prescribed by the doctor, acid reflux drugs are available in the pharmacies antacids for example are ideal for mild acid reflux indication.