These drugs reduce heartburn by reducing the amount of acid your stomach produces most of these drugs are only available on prescription, but there are some that can be obtained over the counter. Over the counter medication for acid reflux south africa. Antacids are alkaline agents (ph > 7) that help in neutralizing the stomach acid and is still one the main medicines used for the treatment of acid reflux and stomach acid disorders antacids continue to be a popular over-the-counter (otc) medicine for indigestion and heartburn even though new generation drugs like proton-pump inhibitors (ppis) and h2 blockers are very effective in reducing.