9 fast-acting natural remedies for heartburn if you’re already experiencing heartburn, your reflex may reach for the antacids these little tablets are alkaline in nature, calming the acid creeping up your esophagus. Acid reflux fast acting heartburn relief. The oldest and best-known medicines for treating heartburn, they have remained popular because they’re fast-acting, inexpensive, available without a prescription, and are safe for most people.
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